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Why Does Physical Dependence Occur?
As one uses more and more of a drug, or any kind of substance, the body develops a drug tolerance. This does not just refer to illegal substances, it can also happen when one drinks coffee on a daily basis. After a while, just one cup may not be enough to get that kick which is neccesary to get going in the morning, or to stay up all night. Thus, a second or third cup may be needed. In the case of drug users, one pill or one puff on x substance may not be enough. The body adapts to the substance that has been introduced. When the drug is no longer available withdrawal symptoms that are the opposite of the direct effects of the drug appear- and this is when the withdrawal occurs. Depending on the elimination half life of the drug, symptoms can arise a few hours after the drug is stopped or may even begin several days after discontinuation of the substance.

Effects of Ecstasy ,The majority of individuals who take ecstasy tell of a pleasant, relaxant effect of the drug. The drug is known to heighten the senses of kindness, affection and a loving feeling, and it is this property which make its abuse potential high. The drug is also known to decrease appetite and sleep- a combination which is highly sought after by the college students. However, the ability of this drug to decrease sleep and increase physical activity endurance combined with its ability to decrease to fluid intake has often resulted in dehydration, exhaustion and even death. Various studies have revealed that even recreational users of the drug might be at risk of developing permanent damage that can manifest depression, anxiety, memory loss, and psychotic disorders.

Oxycontin Abuse and Withdrawal Since the introduction of OxyContin in 1995, there has been a dramatic increase in abuse of this narcotic. Unlike hydrocodone and its derivatives, whose potential for abuse is limited by the presence of aspirin paracetamol, OxyContin contains only oxycodone. The drug is easily abused by simply crushing the tablets and either ingestion, injection, inhalation or placed rectally. The drug can have serious side effects when injected as it has a prolonged extended action. Oxycontin is frequently made more available by "doctor shopping," where individuals, who do not have a legitimate illness, repeatedly visit many doctors to acquire large amounts of controlled substances. Other methods of obtaining oxycontin include pharmacy diversion, robbery, fake/stolen prescription, the internet and improper prescribing practices by physicians. Recent reports indicate that non medical use of Oxycontin is relatively high among teenagers. The increased misuse of the drug has led to a numerous emergency admissions and even deaths. Many States have introduced legislation to decrease the illegal use of Oxycontin. Numerous States have also introduced prescription monitoring and banned the sale of the drug over the internet. Despite all the increased efforts by the FDA, DEA, and state/local authorities, the illicit use of Oxycontin is at an all time high. Over the last decade the increased illicit use of oxycontin has led to the manufacture of fake oxycontin pills all over north America.